crizotinib raises amounts of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Dose reduction may be required for coadministered medicine that are predominantly metabolized by CYP3A.

Akutt og alvorlig allergisk reaksjon med symptomer som feber, utslett, opphovning, pustebesvær og blodtrykksfall. Anafylaktisk sjokk er livstruende om male ikke setter i gang med legemiddelbehandling i kind av antihistaminer og adrenalin.

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triclabendazole will enhance the amount or influence of modafinil by influencing hepatic enzyme CYP2C19 metabolism.

EMA ble opprettet i 1995 for å sikre most effective mulig utnyttelse av Europas vitenskapelige ressurser for evaluering av, tilsyn med og overvåkning av legemidler.

This medication may trigger significant pores and skin reactions. They can transpire weeks to months immediately after beginning the medication. Make contact with your wellbeing treatment supplier without delay if you detect fevers or flu-like signs with a rash.

modafinil will minimize the extent or outcome of diazepam buccal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Potent or average CYP3A4 inducers could raise level of diazepam elimination; therefore, efficacy of diazepam might be decreased.

Precisely the same research also prompt the adolescent Mind is particularly delicate to the effects of stimulants which include methylphenidate

modafinil will boost the stage or impact of diazepam more info buccal by impacting hepatic enzyme CYP2C19 metabolism. Use Caution/Observe. Sturdy or reasonable CYP2C19 inhibitors may perhaps lessen price of diazepam elimination, thereby raising adverse reactions to diazepam.

cenobamate will boost the degree or influence of modafinil by influencing hepatic enzyme CYP2C19 metabolism. Modify Therapy/Observe Closely. Take into account a dose reduction of CYP2C19 substrates, as clinically proper, when utilized concomitantly with cenobamate.

modafinil will decrease the level or influence of mavacamten by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.

The BALCO scandal introduced to mild an unsubstantiated (but widely posted) account of Key League Baseball's all-time top dwelling-run hitter Barry Bonds' supplemental chemical program that involved modafinil Besides anabolic steroids and human expansion hormone.[235]

While modafinil is generally observed to become Protected and considerable adverse results are unusual, like in pediatric narcolepsy scenarios (snooze Diseases in children), there is proof that very long-phrase usage may lead to tolerance in a few individuals.

stiripentol will raise the amount or result of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Observe Carefully. Think about cutting down the dose of CYP2C19 substrates, if adverse reactions are knowledgeable when administered concomitantly with stiripentol.